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Wake up to ADHD symptom control with once-nightly ONYDA™ XR (clonidine HCI)1

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The first liquid non-stimulant for ADHD
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Effective
non-stimulant option

Significant improvements in ADHD symptom control when used alone or when added to an existing stimulant medication based on the study results.2,3

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Easy to
take liquid

As an orange-flavored liquid medicine, ONYDA XR can be easier for children who have difficulty with pills. Dosing at night may also make morning routines easier.

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Eligible patients pay as little as $25 on each prescription!*

*Co-pay offer is subject to eligibility. Terms and Conditions apply.

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One dose at night for consistent medication release through the day1

ONYDA XR is made differently from other clonidine products! With a single night-time dose, our unique technology provides smooth, consistent release through the day.

ADHD, Attention Deficit Hyperactivity Disorder

REFERENCES: 1. ONYDA XR [package insert]. Tris Pharma, Inc., Monmouth Junction, NJ. 2. Jain R, Segal S, Kollins SH, Khayrallah M. Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):171-9. 3. Kollins SH, Jain R, Brams M, Segal S, Findling RL, Wigal SB, Khayrallah M. Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD. Pediatrics. 2011 Jun;127(6):e1406-13.

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Important Safety Information

ONYDA™ XR (clonidine HCI) is a prescription medicine used for the treatment of attention deficit hyperactivity disorder (ADHD) alone or with certain other ADHD medicines in children 6 years of age and older. It is not known if ONYDA XR is safe and effective in children under 6 years of age.

See Additional Important Safety Information.

APPROVED USE

ONYDA™ XR (clonidine HCI) is a prescription medicine used for the treatment of attention deficit hyperactivity disorder (ADHD) alone or with certain other ADHD medicines in children 6 years of age and older.

It is not known if ONYDA XR is safe and effective in children under 6 years of age.

Important Safety Information

Who should not take ONYDA XR?

  • Do not take ONYDA XR if you are allergic to clonidine.

ONYDA XR can cause serious side effects including:

  • Allergic reactions: You may develop an allergic reaction to ONYDA XR if you had an allergic reaction to clonidine taken through your skin in a patch. Stop taking ONYDA XR and call your healthcare provider right away or go to the nearest emergency room if you develop any signs or symptoms of an allergic reaction, including:
    • skin rash
    • hives
    • swelling of the eyes, face, lips, or tongue
  • Decreased blood pressure and heart rate. ONYDA XR can decrease your blood pressure and heart rate, which can increase your chance of passing out (syncope). If you have a history of passing out or have other medical problems as mentioned above, your risk is higher. Your healthcare provider should check your heart rate and blood pressure before starting treatment and regularly during treatment with ONYDA XR. Do not become dehydrated or too hot (overheated) to decrease your chance of passing out during treatment with ONYDA XR. Before taking ONYDA XR, tell your healthcare provider about all of your medical conditions, including if you: have kidney problems, have low or high blood pressure, have heart problems, including slow heart rate or other heart rhythm problems, had a stroke or have stroke symptoms.
  • Sleepiness and tiredness that could cause slow reaction times (sedation and somnolence). Do not drive, operate heavy machinery, or do other dangerous activities until you know how ONYDA XR affects you because ONYDA XR can cause sleepiness and tiredness that could cause slow reaction times. Do not drink alcohol or take other medicines that make you sleepy or dizzy during treatment with ONYDA XR until you talk with your healthcare provider.
  • Rebound high blood pressure (hypertension). Suddenly stopping ONYDA XR can cause high blood pressure to return if you have a history of high blood pressure. Suddenly stopping ONYDA XR may also cause withdrawal symptoms including headache, increased heart rate, nausea, flushing or warm feeling, lightheadedness, tightness in your chest and nervousness or anxiety. Do not suddenly stop ONYDA XR treatment without first talking to your healthcare provider.

The most common side effects of ONYDA XR when used alone include:

  • falling asleep or sleepiness and tiredness that could cause slow reaction times
  • irritability
  • nightmare
  • trouble sleeping
  • constipation
  • dry mouth

The most common side effects of ONYDA XR when used with other ADHD medicines include:

  • falling asleep or sleepiness and tiredness that could cause slow reaction times
  • decreased appetite
  • dizziness

ONYDA XR may cause fertility problems in females and males, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of ONYDA XR. Call your doctor for medical advice about side effects.

ONYDA XR and certain other medicines may affect each other causing serious side effects. Especially tell your healthcare provider if you take:

  • anti-depression medicines
  • heart or blood pressure medicines
  • other medicines for ADHD
  • other medicines that contain clonidine
  • medicines that cause sleepiness (sedation)

Ask your healthcare provider or pharmacist if you are not sure if your medicine is listed above.

Know the medicines that you take. Keep a list of your medicines with you to show your healthcare provider and pharmacist when you get a new medicine.

Before taking ONYDA XR, tell your healthcare provider, if you:

  • are pregnant or plan to become pregnant. It is not known if ONYDA XR will harm the unborn baby.
    There is a pregnancy registry for females who are exposed to ADHD medications, including ONYDA XR, during pregnancy. The purpose of the registry is to collect information about the health of females exposed to ONYDA XR and their baby. If you become pregnant during treatment with ONYDA XR, talk to your healthcare provider about registering with the National Pregnancy Registry of ADHD Medications at 1-866-961-2388 or visit online at https://womensmentalhealth.org/adhdmedications/.
  • are breastfeeding or plan to breastfeed. ONYDA XR passes into the breast milk. Babies who are breastfed during treatment with ONYDA XR may become very sleepy, develop relaxed or floppy muscles, and develop trouble breathing. Call the baby’s healthcare provider if the baby is breastfed during treatment with ONYDA XR and develops any of these symptoms. Talk to your healthcare provider about the best way to feed your baby if you take ONYDA XR.

To report side effects, contact Tris Pharma, Inc. at 1-732-940-0358 or FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information, including Instructions for Use.

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